Kumar, ArunVaca Dempere, Mireia, 1994-Mortimer, ThomasDeryagin, OlegSmith, Jacob G.Petrus, PaulKoronowski, Kevin B.Greco, Carolina M.Segalés Dalmau, JessicaAndrés, EvaLukesova, VeraZinna, Valentina M.Welz, Patrick-SimonSerrano Sánchez, Antonio L.Perdiguero, Eusebio, 1968-Sassone-Corsi, PaoloAznar Benitah, SalvadorMuñoz Cánoves, Pura, 1962-2024-11-132024-11-132024Kumar A, Vaca-Dempere M, Mortimer T, Deryagin O, Smith JG, Petrus P, et al. Brain-muscle communication prevents muscle aging by maintaining daily physiology. Science. 2024 May 3;384(6695):563-72. DOI: 10.1126/science.adj85330036-8075http://hdl.handle.net/10230/68504A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.application/pdfengThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 2024;384(6695), DOI: 10.1126/science.adj8533EnvellimentMúsculsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/science.adj8533info:eu-repo/semantics/openAccess