Toll Privat, AlbaMané Santacana, Anna2015-06-092015-06-092015Toll A, Mané A. Brain-derived neurotrophic factor levels in first episode of psychosis: A systematic review. World J Psychiatry. 2015 Mar 22;5(1):154-9. doi: 10.5498/wjp.v5.i1.154.2220-3206http://hdl.handle.net/10230/23778AIM: To systematically review studies measuring peripheric brain-derived neurotrophic factor (BDNF) levels on first-episode psychosis patients and variables related to them. METHODS: A systematic search was made of articles published in the Medline database from 2002 up to June 2014. Included are original studies that report enzyme-linked immunosorbent assay measurement of BDNF levels in serum or plasma in patients with a diagnosis of first episode psychosis (FEP) and age- and gender- matched healthy controls. RESULTS: Of the initially identified 147 articles, only 18 satisfied the inclusion criteria. Of this, 15 found a significant reduction in patients with FEP compared with age- and gender - matched controls. CONCLUSION: Peripheral BDNF levels are generally reduced in FEP patients. There are some factors that may influence BDNF levels that need to be further studied. Furthermore, a future meta-analysis in this topic is needed.application/pdfengThis article is an open-access article which was/nselected by an in-house editor and fully peer-reviewed by external/nreviewers. It is distributed in accordance with the Creative/nCommons Attribution Non Commercial (CC BY-NC 4.0) license,/nwhich permits others to distribute, remix, adapt, build upon this/nwork non-commercially, and license their derivative works on/ndifferent terms, provided the original work is properly cited and/nthe use is non-commercial. See: http://creativecommons.org//nlicenses/by-nc/4.0/PsicosiCervell -- Fisiologiainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.5498/wjp.v5.i1.154info:eu-repo/semantics/openAccess