Ramon Duaso, Carla, 1987-Conde-Moro, Ana RocioBusquets Garcia, Arnau, 1985-2022-12-192023Ramon-Duaso C, Conde-Moro AR, Busquets-Garcia A. Astroglial cannabinoid signaling and behavior. Glia. 2023 Jan;71(1):60-70. DOI: 10.1002/glia.241710894-1491http://hdl.handle.net/10230/55161In neuroscience, the explosion of innovative and advanced technical accomplishments is fundamental to understanding brain functioning. For example, the possibility to distinguish glial and neuronal activities at the synaptic level and/or the appearance of new genetic tools to specifically monitor and manipulate astroglial functions revealed that astrocytes are involved in several facets of behavioral control. In this sense, the discovery of functional presence of type-1 cannabinoid receptors in astrocytes has led to identify important behavioral responses mediated by this specific pool of cannabinoid receptors. Thus, astroglial type-1 cannabinoid receptors are in the perfect place to play a role in a complex scenario in which astrocytes sense neuronal activity, release gliotransmitters and modulate the activity of other neurons, ultimately controlling behavioral responses. In this review, we will describe the known behavioral implications of astroglial cannabinoid signaling and highlight exciting unexplored research avenues on how astroglial cannabinoid signaling could affect behavior.application/pdfengThis is the peer reviewed version of the following article: Ramon-Duaso C, Conde-Moro AR, Busquets-Garcia A. Astroglial cannabinoid signaling and behavior. Glia. 2023 Jan;71(1):60-70. DOI: 10.1002/glia.24171, which has been published in final form at http://dx.doi.org/10.1002/glia.24171. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/glia.24171D-serineAstrocytesCannabinoid receptorCognitionLactateRodent behaviorSocial behaviorinfo:eu-repo/semantics/openAccess