Larriba, María JesúsGarcía de Herreros, AntonioMuñoz, Alberto2016-04-282016-04-282016Larriba MJ, García de Herreros A, Muñoz A. Vitamin D and the epithelial to mesenchymal transition. Stem Cells Int. 2016;2016:6213872. DOI: 10.1155/2016/62138721687-966Xhttp://hdl.handle.net/10230/26203Several studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and through the repression of key EMT inducers. Both direct and indirect regulatory mechanisms mediate these effects. Conversely, certain master EMT inducers inhibit 1,25(OH)2D3 action by repressing the transcription of VDR gene encoding the high affinity vitamin D receptor that mediates 1,25(OH)2D3 effects. Consequently, the balance between the strength of 1,25(OH)2D3 signaling and the induction of EMT defines the cellular phenotype in each context. Here we review the current understanding of the genes and mechanisms involved in the interplay between 1,25(OH)2D3 and EMT.application/pdfengCopyright © 2016 María Jesús Larriba et al. This is an open access article distributed under the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Vitamina DCèl·lules epitelials -- Aspectes genèticsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2016/6213872info:eu-repo/semantics/openAccess