Correia, TeresaAguirre, JuanSisniega, AlejandroChamorro Servent, JuditAbascal, Juan Felipe Pérez JusteVaquero, Juan J.Desco, ManuelArridge, Simon2018-05-312018-05-312011Correia, Teresa; Aguirre, Juan; Sisniega, Alejandro; Chamorro Servent, Judit; Abascal, Juan; Vaquero, Juan José; Desco, Manuel; Arridge, Simon. Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information. Biomedical Optics Express 2011; 2(9): 2632-48. DOI: 10.1364/BOE.2.0026322156-7085http://hdl.handle.net/10230/34766Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.application/pdfeng© 2011 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1364/BOE.2.002632info:eu-repo/semantics/openAccess