Mayneris Perxachs, JordiArnoriaga Rodríguez, MaríaGarre-Olmo, JosepPuig, JosepRamos, RafelTrelis, MariaBurokas, AurelijusColl, ClàudiaZapata-Tona, CristinaPedraza, SalvadorPérez Brocal, VicenteRamió-Torrentà, LluísRicart, WifredoMoya, AndrésJové, MarionaSol, JoaquimPortero Otín, ManuelPamplona, ReinaldMaldonado, Rafael, 1961-Fernández Real, Jose M.2022-11-102022-11-102022Mayneris-Perxachs J, Arnoriaga-Rodríguez M, Garre-Olmo J, Puig J, Ramos R, Trelis M, et al. Presence of blastocystis in gut microbiota is associated with cognitive traits and decreased executive function. ISME J. 2022 Sep; 16(9): 2181-97. DOI: 10.1038/s41396-022-01262-3.1751-7362http://hdl.handle.net/10230/54786Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery (n = 114) and replication cohorts (n = 942). We also found that Blastocystis was linked to bacterial functions related to aromatic amino acids metabolism and folate-mediated pyrimidine and one-carbon metabolism. Blastocystis-associated shifts in bacterial functionality translated into the circulating metabolome. Finally, we evaluated the effects of microbiota transplantation. Donor's Blastocystis subtypes led to altered recipient's mice cognitive function and prefrontal cortex gene expression. In summary, Blastocystis warrant further consideration as a novel actor in the gut microbiome-brain axis.application/pdfengThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.Blastocist -- InfeccióMicrobiomaCognicióinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41396-022-01262-3info:eu-repo/semantics/openAccess