Ramos Campoy, SilviaPuiggros Metje, Anna MariaGimeno Vázquez, EvaEspinet Solà, Blanca2021-06-172021-06-172022Ramos-Campoy S, Puiggros A, Beà S, Bougeon S, Larráyoz MJ, Costa D et al. Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients. Haematologica. 2022;107(3):593-603. DOI: 10.3324/haematol.2020.2744560390-6078http://hdl.handle.net/10230/47912Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK, 46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity [0-2, 3-4 and ≥5 abnormalities] was also analyzed. No significant differences in the percentage of patients classified into each category were detected, but only a moderate agreement was observed between methods when focusing in individual cases (κ=0.507; p.application/pdfeng© 2021 Ferrata Storti Foundation. Papers in Haematologica are published under a Creative Commons license CC BY-NC-ND. According to this license, an article may be copied, displayed, distributed, republished or otherwise reused provided the reuse is not an adaptation or a modification and the integrity of the original paper is maintained. This license does not allow for any kind of commercial use of the paper. For more details, see About Haematologica.info:eu-repo/semantics/articlehttp://dx.doi.org/10.3324/haematol.2020.274456info:eu-repo/semantics/openAccess