Pérez-Sáez, María JoséArias Cabrales, Carlos EnriqueRedondo Pachón, María DoloresBurballa Tàrrega, Carla, 1988-Buxeda, AnnaBach Pascual, AnnaFaura, AnnaJunyent-Iglesias, ErnestinaMarco, EsterRodríguez-Mañas, LeocadioCrespo Barrio, MartaPascual Santos, JulioFRAIL-MAR Study Group2023-03-062023-03-062022Pérez-Sáez MJ, Arias-Cabrales CE, Redondo-Pachón D, Burballa C, Buxeda A, Bach A, et al. Increased mortality after kidney transplantation in mildly frail recipients. Clin Kidney J. 2022 Jun 23; 15(11): 2089-96. DOI: 10.1093/ckj/sfac1592048-8505http://hdl.handle.net/10230/56036Background: physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1-2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including only those who have 0 criteria, or those with 0-1 criteria. Our aim was to determine the impact of one PFP criterion on transplant outcomes. Methods: we undertook a retrospective study of 296 kidney transplant recipients who had been evaluated for frailty by PFP at the time of evaluating for transplantation. Results: only 30.4% of patients had 0 criteria, and an additional 42.9% showed one PFP criterion. As PFP score increased, a higher percentage of women and cerebrovascular disease were found. Recipients with 0-1 criteria had lower 1-year mortality after transplant than those with ≥2 (1.8% vs 10.1%), but this difference was already present when we only considered those who scored 0 (mortality 1.1%) and 1 (mortality 2.4%) separately. The multivariable analysis confirmed that one PFP criterion was associated to a higher risk of patient death after kidney transplantation [hazard ratio 3.52 (95% confidence interval 1.03-15.9)]. Conclusions: listed kidney transplant candidates frequently show only one PFP frailty criterion. This has an independent impact on patient survival after transplantation.application/pdfengCopyright © Pérez-Sáez MJ, Arias-Cabrales CE, Redondo-Pachón D, Burballa C, Buxeda A, Bach A, et al. 2022. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact moc.puo@snoissimrep.slanruojinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/ckj/sfac159FriedFrailty phenotypeSurvivalTtransplantinfo:eu-repo/semantics/openAccess