Zamora, AlbertoRamos, RafelComas Cufí, MarcGarcía Gil, MariaMartí-Lluch, RuthPlana, NuriaAlves-Cabratosa, LiaPonjoan, AnnaRodríguez-Borjabad, CèliaIbarretxe, DaianaRoman Degano, IreneMarrugat de la Iglesia, JaumeElosua Llanos, RobertoMartin-Urda Diez-Canseco, AnabelMasana, Luís2024-04-262024-04-262023Zamora A, Ramos R, Comas-Cufi M, García-Gil M, Martí-Lluch R, Plana N, et al. Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men. Sci Rep. 2023 Jan 27;13(1):1492. DOI: 10.1038/s41598-023-27963-z2045-2322http://hdl.handle.net/10230/59915Familial hypercholesterolemia (FH) is an autosomal dominant disease that has a prevalence of approximately 1/250 inhabitants and is the most frequent cause of early coronary heart disease (CHD). We included 1.343.973 women and 1.210.671 men with at least one LDL-c measurement from the Catalan primary care database. We identified 14.699 subjects with Familial hypercholesterolemia-Phenotype (FH-P) based on LDL-c cut-off points by age (7.033 and 919 women, and 5.088 and 1659 men in primary and secondary prevention, respectively). Lipid lower therapy (LLT), medication possession ratio (MPR) as an indicator of adherence, and number of patients that reached their goal on lipid levels were compared by sex. In primary and secondary prevention, 69% and 54% of women (P = 0.001) and 64% and 51% of men (P = 0.001) were on low-to-moderate-potency LLT. Adherence to LLT was reduced in women older than 55 years, especially in secondary prevention (P = 0.03), where the percentage of women and men with LDL-c > 1.81 mmol/L were 99.9% and 98.9%, respectively (P = 0.001). Women with FH-P are less often treated with high-intensity LLT, less adherent to LLT, and have a lower probability of meeting their LDL-c goals than men, especially in secondary prevention.application/pdfeng© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-023-27963-zDyslipidaemiasinfo:eu-repo/semantics/openAccess