Petrus, PaulSmith, Jacob G.Koronowski, Kevin B.Chen, SiweiSato, TomokiGreco, Carolina M.Mortimer, ThomasWelz, Patrick-SimonZinna, Valentina M.Shimaji, KoheiCervantes, MarlenePunzo, DanielaBaldi, PierreMuñoz Cánoves, Pura, 1962-Sassone-Corsi, PaoloAznar Benitah, Salvador2022-09-092022-09-092022Petrus P, Smith JG, Koronowski KB, Chen S, Sato T, Greco CM, Mortimer T, Welz PS, Zinna VM, Shimaji K, Cervantes M, Punzo D, Baldi P, Muñoz-Cánoves P, Sassone-Corsi P, Aznar Benitah S. The central clock suffices to drive the majority of circulatory metabolic rhythms. Sci Adv. 2022 Jul;8(26):eabo2896. DOI: 10.1126/sciadv.abo28962375-2548http://hdl.handle.net/10230/54033Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in part, by temporal coordination of metabolism. Here, we characterize the extent to which clocks in different organs control systemic metabolic rhythms, an area that remains largely unexplored. We analyzed the metabolome of serum from mice with tissue-specific expression of the clock gene Bmal1. Having functional hepatic and muscle clocks can only drive a minority (13%) of systemic metabolic rhythms. Conversely, limiting Bmal1 expression to the central pacemaker in the brain restores rhythms to 57% of circulatory metabolites. Rhythmic feeding imposed on clockless mice resulted in a similar rescue, indicating that the central clock mainly regulates metabolic rhythms via behavior. These findings explicate the circadian communication between tissues and highlight the importance of the central clock in governing those signals.application/pdfeng© 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/sciadv.abo2896info:eu-repo/semantics/openAccess