Di Tommaso, PaoloBussotti, Giovanni, 1983-Kemena, Carsten, 1983-Capriotti, EmidioChatzou, Maria, 1985-Prieto Barja, Pablo, 1986-Notredame, Cedric2024-10-212024-10-212014Di Tommaso P, Bussotti G, Kemena C, Capriotti E, Chatzou M, Prieto P, et al. SARA-Coffee web server, a tool for the computation of RNA sequence and structure multiple alignments. Nucleic Acids Res. 2014 Jul 1;42(W1):W356-60. DOI: 10.1093/nar/gku4590305-1048http://hdl.handle.net/10230/68258This article introduces the SARA-Coffee web server; a service allowing the online computation of 3D structure based multiple RNA sequence alignments. The server makes it possible to combine sequences with and without known 3D structures. Given a set of sequences SARA-Coffee outputs a multiple sequence alignment along with a reliability index for every sequence, column and aligned residue. SARA-Coffee combines SARA, a pairwise structural RNA aligner with the R-Coffee multiple RNA aligner in a way that has been shown to improve alignment accuracy over most sequence aligners when enough structural data is available. The server can be accessed from http://tcoffee.crg.cat/apps/tcoffee/do:saracoffee.application/pdfeng© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comFilogèniaRibonucleasesProteïnesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/nar/gku459info:eu-repo/semantics/openAccess