Sans-de San Nicolás, LídiaCzarnowicki, TaliAkdis, MübeccelPujol Vallverdú, Ramon MariaLozano-Ojalvo, DanielLeung, Donald Y. M.Guttman-Yassky, EmmaSantamaria-Babí, Luis F.2024-04-242024-04-242024Nicolàs LSS, Czarnowicki T, Akdis M, Pujol RM, Lozano-Ojalvo D, Leung DYM, et al. CLA+ memory T cells in atopic dermatitis: CLA+ T cells and atopic dermatitis. Allergy. 2024 Jan;79(1):15-25. DOI: 10.1111/all.158160105-4538http://hdl.handle.net/10230/59881Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.application/pdfeng© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/all.15816CLA+ T cellsAtopic dermatitisBiomarkerSkin-homingTranslationalinfo:eu-repo/semantics/openAccess