Hahn, GeraldSkeide, Michael A.Mantini, DanteGanzetti, MarcoDestexhe, AlainFriederici, Angela D.Deco, Gustavo2020-02-172020-02-172019Hahn G, Skeide MA, Mantini D, Ganzetti M, Destexhe A, Friederici AD, Deco G. A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development. Sci Rep. 2019 Jun 11;9(1):8479. DOI: 10.1038/s41598-019-44909-62045-2322http://hdl.handle.net/10230/43619Recently introduced effective connectivity methods allow for the in-vivo investigation of large-scale functional interactions between brain regions. However, dynamic causal modeling, the most widely used technique to date, typically captures only a few predefined regions of interest. In this study, we present an alternative computational approach to infer effective connectivity within the entire connectome and show its performance on a developmental cohort with emerging language capacities. The novel approach provides new opportunities to quantify effective connectivity changes in the human brain.application/pdfengThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-019-44909-6Human experimentNuclear magnetic resonance imagingQuantitative analysisStructure activity relationinfo:eu-repo/semantics/openAccess