García de Herreros, AntonioDuñach, Mireia2019-11-252019-11-252019García de Herreros A, Duñach M. Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization. Cells. 2019 Sep 25;8(10):1148. DOI: 10.3390/cells81011482073-4409http://hdl.handle.net/10230/42948In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by binding of Wnt ligands to the Frizzled/LRP5/6 receptor complex, and it increases the half-life of β-catenin by precluding the phosphorylation of β-catenin by GSK3 and its binding to the βTrCP1 ubiquitin ligase. Other intercellular signals are also activated by Wnt ligands that do not inhibit GSK3 and increase β-catenin protein but that either facilitate β-catenin transcriptional activity or stimulate other transcriptional factors that cooperate with it. In this review, we describe the layers of complexity of these signals and discuss their crosstalk with β-catenin in activation of transcriptional targets.application/pdfeng© García de Herreros A, Duñach M. by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/cells8101148FrizzledLRP5/6ROR2STAT3Wnt signalingYAP/TAZβ-catenininfo:eu-repo/semantics/openAccess