Capdevila, JaumeGómez, Ma AuxiliadoraGuillot, MónicaPaéz, DavidPericay, CarlesSafont, Maria JoséTarazona, NoeliaVera, RuthVidal, JoanaSastre, Javier2022-08-302022-08-302022Capdevila J, Gómez MA, Guillot M, Páez D, Pericay C, Safont MJ, Tarazona N, Vera R, Vidal J, Sastre J. SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2021). Clin Transl Oncol. 2022 Apr;24(4):646-57. DOI: 10.1007/s12094-022-02816-91699-048Xhttp://hdl.handle.net/10230/53939The management of localized rectal cancer requires a multidisciplinary approach to optimize outcomes, reduce morbidity and prevent under or overtreatments. While early stages may obtain benefit of local resections without any additional therapies, locally advanced rectal cancer becomes a challenge defining the better sequential strategy of surgery, radiotherapy and chemotherapy. The latest results of international phase III studies have positioned the total neoadjuvant therapy as a potential new standard of care in high risk rectal cancers, however, the best schedule is still not well defined.application/pdfeng© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s12094-022-02816-9GuidelineRectal cancerTotal neoadjuvant therapyinfo:eu-repo/semantics/openAccess