Dierssen Sotos, TrinidadPalazuelos, CamiloJiménez-Moleón, José JuanAragonés, NúriaAltzibar, Jone MirenCastaño Vinyals, GemmaMartín Sánchez, VicenteGómez-Acebo, InésGuevara, MarcelaTardón, AdoninaPérez-Gómez, BeatrizAmiano, PilarMoreno, VíctorMolina, Antonio J.Alonso Molero, JessicaMoreno-Iribas, ConchiKogevinas, ManolisPollan, MarinaLlorca, Javier2018-10-152018-10-152018Dierssen-Sotos T, Palazuelos-Calderón C, Jiménez-Moleón JJ, Aragonés N, Altzibar JM, Castaño-Vinyals G et al. Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project. BMC Cancer. 2018 Mar 12;18(1):280. DOI: 10.1186/s12885-018-4182-31471-2407http://hdl.handle.net/10230/35609BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.application/pdfengCopyright © The Author(s). 2018. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Mama -- Càncerinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12885-018-4182-3Breast cancerGenetic interactionsReproductive factorsinfo:eu-repo/semantics/openAccess