Kim, KyeezuJoyce, Brian T.Nannini, Drew R.Zheng, YinanGordon-Larsen, PennyShikany, James M.Lloyd-Jones, Donald M.Hu, MingNieuwenhuijsen, Mark J.Vaughan, Douglas E.Zhang, KaiHou, Lifang2023-11-272023-11-272023Kim K, Joyce BT, Nannini DR, Zheng Y, Gordon-Larsen P, Shikany JM, Lloyd-Jones DM, Hu M, Nieuwenhuijsen MJ, Vaughan DE, Zhang K, Hou L. Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status. Sci Adv. 2023 Jun 28;9(26):eadf8140. DOI: 10.1126/sciadv.adf81402375-2548http://hdl.handle.net/10230/58375Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated the association between 20-year exposure to greenness [Normalized Difference Vegetation Index (NDVI)] and epigenetic aging in a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for individual and neighborhood socioeconomic characteristics, greater greenness was associated with slower epigenetic aging. Black participants had less surrounding greenness and an attenuated association between greenness and epigenetic aging [βNDVI5km: -0.80, 95% confidence interval (CI): -4.75, 3.13 versus βNDVI5km: -3.03, 95% CI: -5.63, -0.43 in white participants]. Participants in disadvantaged neighborhoods showed a stronger association between greenness and epigenetic aging (βNDVI5km: -3.36, 95% CI: -6.65, -0.08 versus βNDVI5km: -1.57, 95% CI: -4.12, 0.96 in less disadvantaged). In conclusion, we found a relationship between greenness and slower epigenetic aging, and different associations by social determinants of health such as race and neighborhood socioeconomic status.application/pdfengCopyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.EpigenèticaVegetació urbanainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/sciadv.adf8140info:eu-repo/semantics/openAccess