Livi, Carmen MariaKlus, Petr, 1985-Delli Ponti, Riccardo, 1987-Tartaglia, Gian Gaetano2016-06-012016-06-012016Livi CM, Klus P, Delli Ponti R, Tartaglia GG. catRAPID signature: identification of ribonucleoproteins and RNA-binding regions. Bioinformatics. 2016; 32(5): 773-775. DOI 10.1093/bioinformatics/btv6291367-4803http://hdl.handle.net/10230/26792MOTIVATION: Recent technological advances revealed that an unexpected large number of proteins interact with transcripts even if the RNA-binding domains are not annotated. We introduce catRAPID signature to identify ribonucleoproteins based on physico-chemical features instead of sequence similarity searches. The algorithm, trained on human proteins and tested on model organisms, calculates the overall RNA-binding propensity followed by the prediction of RNA-binding regions. catRAPID signature outperforms other algorithms in the identification of RNA-binding proteins and detection of non-classical RNA-binding regions. Results are visualized on a webpage and can be downloaded or forwarded to catRAPID omics for predictions of RNA targets. AVAILABILITY AND IMPLEMENTATION: catRAPID signature can be accessed at http://s.tartaglialab.com/new_submission/signatureapplication/pdfeng© The Author 2015. Published by Oxford University Press./nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly citedRNAinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/bioinformatics/btv629info:eu-repo/semantics/openAccess