Garriga, CésarGarcia de Olalla, PatriciaMiró, José MaríaOcaña, InmaKnobel Freud, HernandoBarberà, María JesúsHumet, VictoriaDomingo, PereGatell, Josep M.Ribera, EsteveGurguí, MercèMarco, AndrésCaylà i Busqueras, Joan A.Barcelona HIV/AIDS working group2016-01-202016-01-202015Garriga C, García de Olalla P, Miró JM, Ocaña I, Knobel H, Barberá MJ. et al. Mortality, causes of death and associated factors relate to a large HIV population-based cohort. PLoS One. 2015 Dec 30;10(12):e0145701. doi: 10.1371/journal.pone.0145701.1932-6203http://hdl.handle.net/10230/25605INTRODUCTION: Antiretroviral therapy has led to a decrease in HIV-related mortality and to the emergence of non-AIDS defining diseases as competing causes of death. This study estimates the HIV mortality rate and their risk factors with regard to different causes in a large city from January 2001 to June 2013. MATERIALS AND METHODS: We followed-up 3137 newly diagnosed HIV non-AIDS cases. Causes of death were classified as HIV-related, non-HIV-related and external. We examined the effect of risk factors on survival using mortality rates, Kaplan-Meier plots and Cox models. Finally, we estimated survival for each main cause of death groups through Fine and Gray models. MORTALITY RESULTS: 182 deaths were found [14.0/1000 person-years of follow-up (py); 95% confidence interval (CI):12.0-16.1/1000 py], 81.3% of them had a known cause of death. Mortality rate by HIV-related causes and non-HIV-related causes was the same (4.9/1000 py; CI:3.7-6.1/1000 py), external was lower [1.7/1000 py; (1.0-2.4/1000 py)]. SURVIVAL RESULTS: Kaplan-Meier estimate showed worse survival in intravenous drug user (IDU) and heterosexuals than in men having sex with men (MSM). Factors associated with HIV-related causes of death include: IDU male (subHazard Ratio (sHR):3.2; CI:1.5-7.0) and <200 CD4 at diagnosis (sHR:2.7; CI:1.3-5.7) versus ≥500 CD4. Factors associated with non-HIV-related causes of death include: ageing (sHR:1.5; CI:1.4-1.7) and heterosexual female (sHR:2.8; CI:1.1-7.3) versus MSM. Factors associated with external causes of death were IDU male (sHR:28.7; CI:6.7-123.2) and heterosexual male (sHR:11.8; CI:2.5-56.4) versus MSM./nCONCLUSION AND RECOMMENDATION: There are important differences in survival among transmission groups. Improved treatment is especially necessary in IDUs and heterosexual males.application/pdfeng© 2015 Garriga et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.VIH (Virus) -- Tractamentinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0145701info:eu-repo/semantics/openAccess