Di Stefano, Bruno, 1984-Collombet, SamuelGraf, T. (Thomas)2023-12-182023-12-182014Di Stefano B, Collombet S, Graf T. Time-resolved gene expression profiling during reprogramming of C/EBPα-pulsed B cells into iPS cells. Sci Data. 2014 May 27;1(1):140008. DOI: 10.1038/sdata.2014.82052-4463http://hdl.handle.net/10230/58566The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is lengthy and inefficient. The development of a reprogramming system that allows rapid and synchronous reprogramming to pluripotency is imperative for understanding the mechanism of iPSC formation and for future therapeutic applications. We have recently reported that a short expression in mouse primary B cells of the transcription factor C/EBPα before the induction of pluripotency factors increases the iPSC reprogramming efficiency >100-fold, involving 95% of the cells within a week. Here we present a dataset containing the time course of gene expression during this process as determined by microarray and RNA-seq techniques.application/pdfengThis work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/3.0/ Metadata associated with this Data Descriptor is available at http://www.nature.com/sdata/ and is released under the CC0 waiver to maximize reuse.Cèl·lules mareCèl·lulesGenèticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/sdata.2014.8info:eu-repo/semantics/openAccess