Ferránzez Quirante, OliviaGrau Cerrato, SantiagoUrbina, OlatzMojal, SergioRiu Camps, MartaSalas Sanchez, Esther2019-07-162019-07-162018Ferrández O, Grau S, Urbina O, Mojal S, Riu M, Salas E. Validation of a score to identify inpatients at risk of a drug-related problem during a 4-year period. Saudi Pharm J. 2018 Jul;26(5):703-708. DOI: 10.1016/j.jsps.2018.02.0201319-0164http://hdl.handle.net/10230/41999OBJECTIVE: Drug-related problems (DRP) produce high morbidity and mortality. It is therefore essential to identify patients at higher risk of these events. This study aimed to validate a DRP risk score in a large number of inpatients. MATERIAL AND METHODS: Validation of a previously designed score to identify inpatients at risk of experiencing at least one DRP in a tertiary university hospital from 2010 to 2013. DRP were detected by a pharmacy warning system integrated in the electronic medical record. The score included the following variables associated with a higher risk of DRP: prescription of a higher number of drugs, greater comorbidity, advanced age, specific ATC groups and certain major diagnostic categories. RESULTS: The study included a total of 52,987 admissions; of these, at least one DRP occurred in 14.9%. After validation of the score (period range, 2010-2013: 0.746-0.764), the area under the curve (AUC) was 0.751 (95% CI: 0.745-0.756). CONCLUSIONS: This value is higher than those reported in other studies describing validation of risk scores. The score showed good capacity to identify those patients at higher risk of DRP in a much larger sample of inpatients than previously described in the literature. This tool allows optimization of drug therapy monitoring in admitted patients.application/pdfeng1319-0164/2018 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jsps.2018.02.020Computerized medical record systemComputerized physician order entryDrug-related problemsPatient safetyRisk scoreinfo:eu-repo/semantics/openAccess