Sánchez-Rodriguez, EstefaníaLima-Cabello, ElenaBiel-Glesson, SaraFernández-Navarro, Jose-RamónCalleja, Miguel AngelRoca Bigorra, MariaEspejo-Calvo, Juan A.Gil-Extremera, BlasSoria-Florido, MariaTorre Fornell, Rafael de laFitó Colomer, MontserratCovas Planells, Maria IsabelAlche, Juan de DiosMartínez de Victoria, EmilioGil, AngelMesa, Maria-Dolores2018-11-132018-11-132018Sanchez-Rodriguez E, Lima-Cabello E, Biel-Glesson S, Fernandez-Navarro JR, Calleja MA, Roca M et al. Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial. Nutrients. 2018;10(5):e626. DOI: 10.3390/nu100506262072-6643http://hdl.handle.net/10230/35741The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).application/pdfeng© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/nu10050626Olive oilVirgin olive oilOlive oil polyphenolsMaslinic acidOleanolic acidCardiovascular diseasesEndothelial functionPhenolic compoundsTriterpenesMetabolic syndromeinfo:eu-repo/semantics/openAccess