Grasset, Emilie K.Cerutti, Andrea, 1965-2021-11-042021-11-042020Grasset EK, Cerutti A. Mutations make gut antibodies promiscuous. J Exp Med. 2020 Nov 2; 217(11): e20201340. DOI: 10.1084/jem.202013400022-1007http://hdl.handle.net/10230/48899In this issue, Kabbert et al. (https://doi.org/10.1084/jem.20200275) show that intestinal antibodies from healthy subjects or patients with Crohn's disease cross-target diverse but distinct communities of the gut microbiota through a mechanism involving somatic hypermutation but not germline-encoded polyreactivity.application/pdfengThis article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/)ImmunoglobulinesIntestins--MicrobiologiaCrohn, Malaltia deinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1084/jem.20201340info:eu-repo/semantics/openAccess