Raote, IshierMalhotra, Vivek2019-09-172019-09-172019Raote I, Malhotra V. Protein transport by vesicles and tunnels. J Cell Biol. 2019 Mar 4;218(3):737-9. DOI: 10.1083/jcb.2018110730021-9525http://hdl.handle.net/10230/42286Palade's corpus placed small vesicles as the sole means to transport proteins across stable distinct compartments of the secretory pathway. We suggest that cargo, spatial organization of secretory compartments, and the timing of fission of cargo-filled containers dictate the design of transport intermediates that can be vesicles and transient direct tunnels.application/pdfeng© 2019 Raote and Malhotra. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/)info:eu-repo/semantics/articlehttp://dx.doi.org/10.1083/jcb.201811073info:eu-repo/semantics/openAccess