Buist-Bouwman, M.A.Ormel, Johande Graaf, Ronde Jonge, Petervan Sonderen, EricAlonso Caballero, JordiBruffaerts, RonnyVollebergh, WilmaESEMeD/MHEDEA 2000 investigators2019-03-142019-03-142008Buist-Bouwman MA, Ormel J, de Graaf R, de Jonge P, van Sonderen E, Alonso J et al. Mediators of the association between depression and role functioning. Acta Psychiatr Scand. 2008 Dec;118(6):451-8. DOI: 10.1111/j.1600-0447.2008.01285.x0001-690Xhttp://hdl.handle.net/10230/36822OBJECTIVE: While the adverse effect of Major Depressive Episode on role functioning is well established, the exact pathways remain unclear. METHOD: Data from The European Study of the Epidemiology of Mental Disorders, a cross-sectional survey including 21 425 adults from six European countries, were used to assess 12-month depression (Composite International Diagnostic Interview), activity limitations and role functioning in the past 30 days (Disability Assessment Schedule). An a priori model based on the World Health Organization's International Classification of Functioning, Disability and Health was designed and a structural equation model for categorical and ordinal data was used (MPlus) to estimate the extent to which six limitations mediated the association between depression and role functioning. RESULTS: The unadjusted association between depression and role functioning was strong (0.43; SE = 0.04). In the best-fitting model, only concentration and attention problems and embarrassment mediated a significant amount of association (direct effect dropped to 0.17; SE = 0.10, which was no longer significant). CONCLUSIONS: Targeting cognition and embarrassment in treatment could help reduce depression-associated role disfunctioning.application/pdfeng© 2008 M.A. Buist-Bouwman et al. Mediators of the association between depression and role functioning. M.A. Buist-Bouwman et al. Acta Psychiatrica Scandinavica, vol. 118, núm. 6Depressió psíquicainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/j.1600-0447.2008.01285.xinfo:eu-repo/semantics/openAccess