Eladly, Ahmed FayedIvorra Cano, AntoniUniversitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions2024-03-162024-03-162021-04-302022-04-282021-04-28http://hdl.handle.net/10230/47283This thesis was conducted within the framework of the eAXON project that is aimed at developing injectable wireless sub-millimetric single-channel addressable microstimulators based on volume conduction called eAXONs that could be inserted in large numbers to provide high density neuromuscular stimulation for restoring functional movement to paralyzed limbs with minimal invasiveness. It is demonstrated that multi-channel intramuscular stimulation significantly delays electrically–induced muscle fatigue, while single-channel stimulation does not. It is shown that the nerve supply of mammalian skeletal muscles appear to be extensively compartmentalized. Meaning, a large number of eAXONs can be implanted, while their independence is maintained. Lastly, the eAXONs are very thin because they act as rectifiers and perform neurostimulation by instantaneously transforming bursts of externally applied volume conducted high frequency currents into low frequency waveforms. Waveforms created with this approach are less current, charge, energy efficient than square waveforms conventionally used in neurostimulation. Therefore, with eAXONs, there is a tradeoff between device miniaturization and stimulation efficiency.Programa de doctorat en Tecnologies de la Informació i les Comunicacions155 p.application/pdfapplication/pdfengL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessinfo:eu-repo/semantics/doctoralThesisIntramusculariIterleavedMinimally invasiveVolume conductionFatigueStimulation efficiency62