Baenas, IsabelMiranda-Olivos, RominaGranero, RoserSolé Morata, Neus, 1988-Sánchez, IsabelPastor, AntonioPino-Gutiérrez, Amparo delCodina, EsterTinahones Madueño, Francisco JoséFernández-Formoso, José A.Vilarrasa, NuriaGuerrero-Pérez, FernandoLopez-Urdiales, RafaelVirgili, NúriaSoriano-Mas, CarlesJiménez Murcia, SusanaTorre Fornell, Rafael de laFernández Aranda, Fernando2023-07-112023-07-112023Baenas I, Miranda-Olivos R, Granero R, Solé-Morata N, Sánchez I, Pastor A, Del Pino-Gutiérrez A, Codina E, Tinahones FJ, Fernández-Formoso JA, Vilarrasa N, Guerrero-Pérez F, Lopez-Urdiales R, Virgili N, Soriano-Mas C, Jiménez-Murcia S, de la Torre R, Fernández-Aranda F. Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity. Eur Psychiatry. 2023 May 31;66(1):e49. DOI: 10.1192/j.eurpsy.2023.24110924-9338http://hdl.handle.net/10230/57525Background: Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence pathophysiology. Then, we aimed to analyze fasting AEA and 2-AG plasma concentrations among individuals with EWC (i.e., anorexia nervosa [AN] and obesity with and without eating disorders [EDs]) compared with healthy controls (HCs), and its association with clinical variables and body mass index (BMI). Methods: The sample included 113 adult women. Fifty-seven belonged to the obesity group, 37 without EDs (OB-ED) and 20 with ED (OB+ED classified within the binge spectrum disorders), 27 individuals from the AN group, and 29 from the HC group. Peripheral blood samples, several clinical variables, and BMI were evaluated. Results: Unlike 2-AG, AEA concentrations showed significant differences between groups (p < 0.001). Increased AEA was observed in the OB-ED and OB+ED compared with both HC and AN group, respectively. Likewise, AEA was differentially associated with emotional dysregulation, general psychopathology, food addiction, and BMI in all clinical groups. Conclusions: These results support the interaction between biological and clinical factors contributing to delineating vulnerability pathways in EWC that could help fit personalized therapeutic approaches.application/pdfeng© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1192/j.eurpsy.2023.24112-arachidonoylglycerolAnandamideEating disordersEndocannabinoidsObesityinfo:eu-repo/semantics/openAccess