Espinosa Blay, LluísMarruecos, Laura2022-05-202022-05-202021Espinosa L, Marruecos L. NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and càncer. Biomedicines. 2021 Sep 21; 9(9): 1278. DOI: 10.3390/biomedicines90912782227-9059http://hdl.handle.net/10230/53187IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.application/pdfengCopyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/biomedicines9091278IκBαNF-κBSUMOylationCancerinfo:eu-repo/semantics/openAccess