Fernandez, Mariana F.Pumarega Rodríguez, José AntonioPorta Serra, MiquelMolina-Molina, Jose ManuelArrebola, Juan PedroOlea, Nicolás2018-03-022017Fernandez MF, Pumarega J, Porta M, Molina-Molina JM, Arrebola JP, Olea N. Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up. Reprod Toxicol. 2017 Apr;69:212-220. DOI: 10.1016/j.reprotox.2017.03.0070890-6238http://hdl.handle.net/10230/34032We aimed to assess changes in the total effective xenoestrogen burden (TEXB) -a biomarker of combined effect of mixtures of xenoestrogens- in breast cancer patients at surgery (breast adipose tissue) and at different time points during an 18-month follow-up (abdominal adipose tissue), and to analyze the potential influence of socio-demographic, reproductive, tumor, and treatment characteristics on TEXB levels. TEXB-alpha (due to persistent organohalogenated chemicals) and TEXB-beta (due mainly to endogenous estrogens) were quantified in 44 women. TEXB values significantly increased over follow-up (p <0.001); the largest difference was observed at 6-12 months post-surgery (p <0.001); then decreased over time. TEXB-alpha at 6-18 months was significantly higher in younger patients with estrogen receptor positivity (p=0.034) and in those receiving anti-neoplasm chemotherapy. Cancer treatment may be responsible for the increase in TEXB-alpha observed in patients with hormone-dependent tumors, which may confer to xenoestrogens a role in the progression of the disease.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.reprotox.2017.03.007Càncer -- TractamentQuimioteràpiainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.reprotox.2017.03.007TEXBBreast cancerCancer treatmentChemotherapyEstrogen receptor tumorsFollow upTotal effective xenoestrogen burdeninfo:eu-repo/semantics/openAccess