Colomer Montañà, Carlota, 1990-Marruecos, LauraVert, AnnaBigas Salvans, AnnaEspinosa Blay, Lluís2018-04-112018-04-112017Colomer C, Marruecos L, Vert A, Bigas A, Espinosa L. NF-κB Members Left Home: NF-κB-Independent Roles in Cancer. Biomedicines. 2017 May 25;5(2). pii: E26. DOI: 10.3390/biomedicines50200262227-9059http://hdl.handle.net/10230/34331Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB members in NF-κB unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of IκB kinase complexes (IKKs) and IκBs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development.application/pdfengCopyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).CàncerProteïnesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/biomedicines5020026CancerIKKsIκBsNF-κBNon-conventional pathwaysinfo:eu-repo/semantics/openAccess