Gaviraghi, MarcoVivori, Claudia, 1989-Tonon, Giovanni2020-04-142020-04-142019Gaviraghi M, Vivori C, Tonon G. How cancer exploits ribosomal RNA biogenesis: A journey beyond the boundaries of rRNA transcription. Cells. 2019; 8(9). pii: E1098. DOI: 10.3390/cells80910982073-4409http://hdl.handle.net/10230/44205The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we will summarize how oncogenes and tumor suppressors modulate the biosynthesis of the RNA component of ribosomes, starting from the description of well-characterized pathways that converge on ribosomal RNA transcription while including novel insights that reveal unexpected regulatory networks hacked by cancer cells to unleash ribosome production.application/pdfeng© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/cells8091098CancerDecappingOncogenesRibosomal RNA (rRNA)RibosomesSmall nucleolar RNAs (snoRNA)info:eu-repo/semantics/openAccess