Tamborero Noguera, DavidRubio Pérez, Carlota, 1990-Déu Pons, JordiSchroeder, Michael Philipp, 1986-Vivancos Prellezo, AnaRovira Guerín, AnaTusquets Trias de Bes, IgnacioAlbanell Mestres, JoanRodon, JordiTabernero Cartula, JosepTorres, Carmen deDienstmann, RodrigoGonzález-Pérez, AbelLópez Bigas, Núria2018-05-092018-05-092018Tamborero D, Rubio-Perez C, Deu-Pons J, Schroeder MP, Vivancos A, Rovira A et al. Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations. Genome Med. 2018 Dec;10(1):25. DOI: 10.1186/s13073-018-0531-81756-994Xhttp://hdl.handle.net/10230/34593While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. The results are organized in different levels of evidence according to current knowledge, which we envision can support a broad range of oncology use cases. The resource is publicly available at http://www.cancergenomeinterpreter.org.application/pdfeng© The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s13073-018-0531-8NeoplasmsCancer genome interpreterinfo:eu-repo/semantics/openAccess