Canal de Torres, Berta, 1988-Duch, AlbaPosas Garriga, FrancescNadal Clanchet, Eulàlia de2018-12-202018-12-202018Canal B, Duch A, Posas F, de Nadal E. A novel mechanism for the prevention of transcription replication conflicts. Mol Cell Oncol. 2018;5(3):e1451233. DOI: 10.1080/23723556.2018.14512332372-3556http://hdl.handle.net/10230/36164Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves to delay replication in response to different stresses that trigger a massive transcriptional response in S phase. This mechanism prevents Transcription-Replication Conflicts and maintains genomic integrity in response to unscheduled massive transcription during S phase.application/pdfeng© 2018 Berta Canal, Alba Duch, Francesc Posas, and Eulàlia de Nadal. Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/23723556.2018.1451233Cellular stressGenomic instabilityMrc1Signaling kinasesTranscription replication conflictsinfo:eu-repo/semantics/openAccess