Fernández, CastaliaNavarro-Martin, ArturoBobo, AndreaCabrera-Rodriguez, JoaquínCalvo, PatriciaChicas-Sett, RodolfoLuna, JavierRodríguez de Dios, NúriaCouñago, Felipe2022-10-212022-10-212022Fernández C, Navarro-Martin A, Bobo A, Cabrera-Rodriguez J, Calvo P, Chicas-Sett R, Luna J, Rodríguez de Dios N, Couñago F. Single-fraction stereotactic ablative body radiation therapy for primary and metastasic lung tumor: A new paradigm?. World J Clin Oncol. 2022 Feb 24;13(2):101-15. DOI: 10.5306/wjco.v13.i2.1012218-4333http://hdl.handle.net/10230/54524Stereotactic ablative body radiotherapy (SABR) is an effective technique comparable to surgery in terms of local control and efficacy in early stages of non-small cell lung cancer (NSCLC) and pulmonary metastasis. Several fractionation schemes have proven to be safe and effective, including the single fraction (SF) scheme. SF is an option cost-effectiveness, more convenience and comfortable for the patient and flexible in terms of its management combined with systemic treatments. The outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic has driven this not new but underutilized paradigm, recommending this option to minimize patients' visits to hospital. SF SABR already has a long experience, strong evidence and sufficient maturity to reliably evaluate outcomes in peripheral primary NSCLC and there are promising outcomes in pulmonary metastases, making it a valid treatment option; although its use in central locations, synchronous and recurrencies tumors requires more prospective safety and efficacy studies. The SABR radiobiology study, together with the combination with systemic therapies, (targeted therapies and immunotherapy) is a direction of research in both advanced disease and early stages whose future includes SF.application/pdfeng© The Author(s) 2022. This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/.info:eu-repo/semantics/articlehttp://dx.doi.org/10.5306/wjco.v13.i2.101Lung cancerLung metastasesNon-small cell lung cancerRadiosurgeryStereotactic body radiotherapySterotactic ablative body radiotherapyinfo:eu-repo/semantics/openAccess