Muñoz-Ortiz, TamaraHu, JieOrtgies, Dirk H.Shrikhande, ShreyaZamora Pérez, Paula, 1988-Granado, MiriamGonzález-Hedström, DanielFuente-Fernández, María de laGarcía-Villalón, Ángel LuisAndrés-Delgado, LauraMartín Rodríguez, EmmaAguilar Torres, RíoAlfonso, FernandoGarcía Solé, JoséRivera Gil, Pilar, 1976-Jaque, DanielRivero, Fernando2022-03-222022-03-222021Muñoz-Ortiz T, Hu J, Ortgies DH, Shrikhande S, Zamora-Perez P, Granado M, González-Hedström D, de la Fuente-Fernández M, García-Villalón ÁL, Andrés-Delgado L, Martín Rodríguez E, Aguilar R, Alfonso F, García Solé J, Rivera Gil P, Jaque D, Rivero F. Molecular imaging of infarcted heart by biofunctionalized gold nanoshells. Adv Healthc Mater. 2021 May;10(10):e2002186. DOI: 10.1002/adhm.2020021862192-2640http://hdl.handle.net/10230/52746The unique combination of physical and optical properties of silica (core)/gold (shell) nanoparticles (gold nanoshells) makes them especially suitable for biomedicine. Gold nanoshells are used from high-resolution in vivo imaging to in vivo photothermal tumor treatment. Furthermore, their large scattering cross-section in the second biological window (1000-1700 nm) makes them also especially adequate for molecular optical coherence tomography (OCT). In this work, it is demonstrated that, after suitable functionalization, gold nanoshells in combination with clinical OCT systems are capable of imaging damage in the myocardium following an infarct. Since both inflammation and apoptosis are two of the main mechanisms underlying myocardial damage after ischemia, such damage imaging is achieved by endowing gold nanoshells with selective affinity for the inflammatory marker intercellular adhesion molecule 1 (ICAM-1), and the apoptotic marker phosphatidylserine. The results here presented constitute a first step toward a fast, safe, and accurate diagnosis of damaged tissue within infarcted hearts at the molecular level by means of the highly sensitive OCT interferometric technique.application/pdfengThis is the peer reviewed version of the following article: Muñoz-Ortiz T, Hu J, Ortgies DH, Shrikhande S, Zamora-Perez P, Granado M, González-Hedström D, de la Fuente-Fernández M, García-Villalón ÁL, Andrés-Delgado L, Martín Rodríguez E, Aguilar R, Alfonso F, García Solé J, Rivera Gil P, Jaque D, Rivero F. Molecular imaging of infarcted heart by biofunctionalized gold nanoshells. Adv Healthc Mater. 2021 May;10(10):e2002186. DOI: 10.1002/adhm.202002186, which has been published in final form at http://dx.doi.org/10.1002/adhm.202002186. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/adhm.202002186Gold nanoshellsInfarctionsOptical coherence tomographySurface functionalizationinfo:eu-repo/semantics/openAccess