Singh, Babita, 1986-Eyras Jiménez, Eduardo2017-07-062017-07-062017Singh B, Eyras Jiménez E. The role of alternative splicing in cancer. Transcription. 2017;8(2):91-8. DOI: 10.1080/21541264.2016.12682452154-1264http://hdl.handle.net/10230/32514The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types. Some of these alterations have been linked to tumor progression, metastasis, therapy resistance, and other oncogenic processes. Here, we describe the different mechanisms that drive splicing changes in tumors and their impact in cancer. Motivated by the current evidence, we propose a model whereby a subset of the splicing patterns contributes to the definition of specific tumor phenotypes, and may hold potential for the development of novel clinical biomarkers and therapeutic approaches.application/pdfeng© 2017 The Author(s). Published with license by Taylor & Francis© Babita Singh and Eduardo Eyras. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/21541264.2016.1268245Alternative splicingCancerBiomarkersRNA processingSplicing regulationTherapyinfo:eu-repo/semantics/openAccess