Díez Antón, Juana, 1962-Jungfleisch, Jennifer, 1986-2017-06-222017-06-222017Díez Antón J, Jungfleisch J. Translation control: Learning from viruses, again. RNA Biology. 2017;14(7):835-7. DOI: 10.1080/15476286.2017.13250681547-6286http://hdl.handle.net/10230/32391Viruses are powerful tools to uncover cellular processes. Through viral studies we have recently identified a novel translational control mechanism that involves the DEAD-box helicase Dhh1/DDX6 and RNA folding within coding sequences (CDSs). All Dhh1-dependent mRNAs, viral and cellular ones, (i) contain long and highly structured CDSs, (ii) are directly bound by Dhh1 with a specific pattern, (iii) are activated at the translation initiation step and (iv) express proteins associated with the endoplasmic reticulum. The obtained results uncover a novel layer of translation regulation associated with translation at the endoplasmic reticulum conserved from yeast to humans and hijacked by viruses.application/pdfeng© Taylor & Francis. This is an electronic version of an article published in Díez Antón J, Jungfleisch J. Translation control: Learning from viruses, again. RNA Biology. 2017 [Epub ahead of print]. RNA Biology is available online at: www.tandfonline.com http://dx.doi.org/10.1080/15476286.2017.1325068.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/15476286.2017.1325068BMVDhh1HelicaseRNA secondary structureTranslational regulationViral RNAinfo:eu-repo/semantics/openAccess