Castellví Fernández, QuimGinestà, Mireia M.Capellá, GabrielIvorra Cano, Antoni, 1974-2016-04-282016-04-282015Castellví Q, Ginestà MM, Capellà G, Ivorra A. Tumor growth delay by adjuvant alternating electric fields which appears non-thermally mediated. Bioelectrochemistry. 2015;105:16-24. doi:10.1016/j.bioelechem.2015.04.0061567-5394http://hdl.handle.net/10230/26210Delivery of the so-called Tumor Treatment Fields (TTFields) has been proposed as a cancer/ntherapy. These are low magnitude alternating electric fields at frequencies from 100 to 300 kHz/nwhich are applied continuously in a non-invasive manner. Electric field delivery may produce an/nincrease in temperature which cannot be neglected. We hypothesized that the reported results/nobtained by applying TTFields in vivo could be due to heat rather than to electrical forces as/npreviously suggested. Here it is presented an in vivo study in which pancreatic tumors/nsubcutaneously implanted in nude mice were treated for a week either with mild hyperthermia/n(41°C) or with TTFields (6 V/cm, 150 kHz) and tumor growth was assessed. Although the TTFields/napplied singly did not produce any significant effect, the combination with chemotherapy did show/na delay in tumor growth in comparison to animals treated only with chemotherapy (median relative/nreduction = 47%). We conclude that concomitant chemotherapy and TTFields delivery show a/nbeneficial impact on pancreatic tumor growth. Contrary to our hypothesis, this impact is nonrelated/nwith the induced temperature increase.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.bioelechem.2015.04.006info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bioelechem.2015.04.006Alternating electric fieldHyperthermiaChemotherapeutic adjuvantPancreatic tumorTTFieldsinfo:eu-repo/semantics/openAccess