Rubio Pérez, Carlota, 1990-Tamborero Noguera, DavidSchroeder, Michael Philipp, 1986-Antolín Hernández, Albert, 1984-Déu Pons, JordiPérez Llamas, Christian, 1976-Mestres i López, JordiGonzález-Pérez, AbelLópez Bigas, Núria2017-10-252017-10-252015Rubio-Perez C, Tamborero D, Schroeder MP, Antolín AA, Deu-Pons J, Perez-Llamas C et al. In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities. Cancer Cell. 2015 Mar 9;27(3):382-96. DOI: 10.1016/j.ccell.2015.02.0071535-6108http://hdl.handle.net/10230/33093Large efforts dedicated to detect somatic alterations across tumor genomes/exomes are expected to produce significant improvements in precision cancer medicine. However, high inter-tumor heterogeneity is a major obstacle to developing and applying therapeutic targeted agents to treat most cancer patients. Here, we offer a comprehensive assessment of the scope of targeted therapeutic agents in a large pan-cancer cohort. We developed an in silico prescription strategy based on identification of the driver alterations in each tumor and their druggability options. Although relatively few tumors are tractable by approved agents following clinical guidelines (5.9%), up to 40.2% could benefit from different repurposing options, and up to 73.3% considering treatments currently under clinical investigation. We also identified 80 therapeutically targetable cancer genes.application/pdfeng© Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.ccell.2015.02.007 that appeared in the journal Cancer Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: https://www.elsevier.com/about/our-business/policies/open-access-licenses/elsevier-user-licenseinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ccell.2015.02.007Antineoplastic AgentsCarcinogenesis/geneticsClinical ProtocolsClinical Trials as TopicCohort StudiesComputational BiologyDNA Mutational AnalysisDrug RepositioningDecision Making, Computer-AssistedNeoplasms/drug therapyNeoplasms/geneticsPrecision Medicine/methodsinfo:eu-repo/semantics/openAccess