Castellano Hereza, SergiGladyshev, Vadim N.Guigó Serra, RodericBerry, Marla J.2011-11-282011-11-282008Castellano S, Gladyshev V N, Guigó R, Berry M J. SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements. Nucleic acids research. 2008; 36 supl 1: D332-D338. DOI: 10.1093/nar/gkm7310305-1048http://hdl.handle.net/10230/13147Selenoproteins are a diverse group of proteins/nusually misidentified and misannotated in sequence/ndatabases. The presence of an in-frame UGA (stop)/ncodon in the coding sequence of selenoprotein/ngenes precludes their identification and correct/nannotation. The in-frame UGA codons are recoded/nto cotranslationally incorporate selenocysteine,/na rare selenium-containing amino acid. The development/nof ad hoc experimental and, more recently,/ncomputational approaches have allowed the efficient/nidentification and characterization of the/nselenoproteomes of a growing number of species./nToday, dozens of selenoprotein families have been/ndescribed and more are being discovered in recently/nsequenced species, but the correct genomic annotation/nis not available for the majority of these/ngenes. SelenoDB is a long-term project that aims to/nprovide, through the collaborative effort of experimental/nand computational researchers, automatic/nand manually curated annotations of selenoprotein/ngenes, proteins and SECIS elements. Version 1.0 of/nthe database includes an initial set of eukaryotic/ngenomic annotations, with special emphasis on the/nhuman selenoproteome, for immediate inspection/nby selenium researchers or incorporation into more/ngeneral databases. SelenoDB is freely available at/nhttp://www.selenodb.org.application/pdfeng© 2007 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Published article is also available at http://nar.oxfordjournals.org/content/36/suppl_1/D332.Biologia molecularBioinformàticaGenòmica -- Bases de dadesGenòmica -- Informàticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/nar/gkm7313'UTRProtein databasesGenomicsHumansInternetSelenoproteinsProtein Sequence AnalysisRNA Sequence AnalysisUser-Computer Interfaceinfo:eu-repo/semantics/openAccess