Dall'Olio, Giovanni Marco, 1983-Vahdati, Ali R.Bertranpetit, Jaume, 1952-Wagner, AndreasLaayouni, Hafid, 1968-2018-04-192018-04-192015Dall'Olio GM, Vahdati AR, Bertranpetit J, Wagner A, Laayouni H. VCF2Networks: applying genotype networks to single-nucleotide variants data. Bioinformatics. 2015 Feb 1;31(3):438-9. DOI: 10.1093/bioinformatics/btu6501367-4803http://hdl.handle.net/10230/34404SUMMARY: A wealth of large-scale genome sequencing projects opens the doors to new approaches to study the relationship between genotype and phenotype. One such opportunity is the possibility to apply genotype networks analysis to population genetics data. Genotype networks are a representation of the set of genotypes associated with a single phenotype, and they allow one to estimate properties such as the robustness of the phenotype to mutations, and the ability of its associated genotypes to evolve new adaptations. So far, though, genotype networks analysis has rarely been applied to population genetics data. To help fill this gap, here we present VCF2Networks, a tool to determine and study genotype network structure from single-nucleotide variant data. AVAILABILITY AND IMPLEMENTATION: VCF2Networks is available at https://bitbucket.org/dalloliogm/vcf2networks. CONTACT: giovanni.dallolio@kcl.ac.uk. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.application/pdfeng© Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Bioinformatics following peer review. The definitive publisher-authenticated version Dall'Olio GM, Vahdati AR, Bertranpetit J, Wagner A, Laayouni H. VCF2Networks: applying genotype networks to single-nucleotide variants data. Bioinformatics. 2015 Feb 1; 31(3): 438-9 is available online at: http://dx.doi.org/10.1093/bioinformatics/btu650GenèticaGenètica de poblacionsGenoma humàGenètica humana -- Variacióinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/bioinformatics/btu650info:eu-repo/semantics/openAccess