Księżopolska, EwaGabaldón Estevan, Juan AntonioUniversitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut2024-10-192024-10-192021-09-082022-07-052021-07-05http://hdl.handle.net/10230/48431This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to find the mutational signatures of drug resistance and cross-resistance to representatives of two clinically important antifungal drug classes, azoles and echinocandins. By combining in vitro evolution with phenotypic screening and comparative genomics analysis we investigated the relationship between genomic changes, fitness and drug susceptibility to shed light on the cellular mechanisms and evolutionary constraints of antifungal drug resistance in this important pathogenPrograma de doctorat en Biomedicina232 p.application/pdfapplication/pdfengL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació deles condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessinfo:eu-repo/semantics/doctoralThesisCandida glabrataExperimental evolutionAntifungalDrug resistanceCross resistanceMultidrug resistanceResistencia a fármacos antimicóticos615