Lázaro, IolandaCofán, MontserratAmor, Antonio J.Ortega, EmilioFreitas-Simoes, Tania-MarisaLlull, LauraAmaro, SergioMestres, GasparYugueros, XavierHarris, William S.Riambau-Alonso, VicenteSala Vila, Aleix2022-02-172022-02-172021Lázaro I, Cofán M, Amor AJ, Ortega E, Freitas-Simoes TM, Llull L, et al. Linoleic acid status in cell membranes inversely relates to the prevalence of symptomatic carotid artery disease. Stroke. 2021 Jan; 52(2): 703-6. DOI: 10.1161/STROKEAHA.120.0304770039-2499http://hdl.handle.net/10230/52514Background and purpose: The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease. Methods: We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography. Results: In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022-0.607], P=0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids. Conclusions: Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.application/pdfeng© American Hearth Association http://dx.doi.org/10.1161/STROKEAHA.120.030477info:eu-repo/semantics/articlehttp://dx.doi.org/10.1161/STROKEAHA.120.030477Alpha-linolenic acidCarotid endarterectomyDietary fatsDocosahexaenoic acidPhospholipidsinfo:eu-repo/semantics/openAccess