Zhou, TingVicente García, Rubén, 1978-Rivera Gil, Pilar, 1976-2024-11-152024-11-152024Zhou T, Vicente R, Rivera-Gil P. Optical monitoring of labile zinc inside metastatic cells with plasmonic chemonanosensors. ACS Omega. 2024 Oct 3;9(41):42183-92. DOI: 10.1021/acsomega.4c036312470-1343http://hdl.handle.net/10230/68700We report the development and characterization of an optical nanosensor for the detection of labile zinc in biological environments. The readout is based on surface-enhanced Raman scattering promoted by a Raman reporter conjugated to the inner plasmonic cavity of hollow silica nanocapsules. We quantify Zn2+ by obtaining the ratio between a Zn2+-sensitive band and a Zn2+-insensitive band. The Raman reporter measures within the range from 10-5 to 10-11 M and exhibits a limit of detection of 10-11.72 M. The nanosensor discriminates between intracellular and extracellular Zn2+ concentrations.application/pdfengThis article is licensed under CC-BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.1021/acsomega.4c03631CancerCellsNanodevicesRaman spectroscopyZincinfo:eu-repo/semantics/openAccess