Cruz-Lemini, MónicaCrispi Brillas, FàtimaValenzuela Alcaraz, BrendaFigueras, FrancescSitges, MartaBijnens, BartGratacós Solsona, Eduard2018-11-292018-11-292016Cruz-Lemini M, Crispi F, Valenzuela-Alcaraz B, Figueras F, Sitges M, Bijnens B, Gratacós E. Fetal cardiovascular remodelling persists at 6 months of life in infants with intrauterine growth restriction. Ultrasound Obstet Gynecol. 2016;48(3):349-56. DOI: 10.1002/uog.157670960-7692http://hdl.handle.net/10230/35887Objectives Intrauterine growth restriction is associated with increased cardiovascular risk later in life but the link between fetal disease and postnatal risk is not well‐documented. We evaluated longitudinally the association between cardiovascular remodeling in small‐for‐gestational‐age (SGA) fetuses and at 6 months of age. Methods A cohort of 80 SGA fetuses (defined by estimated fetal and birth weights < 10th centile) delivered > 34 weeks' gestation was compared with 80 normally grown age‐matched control fetuses, with follow‐up at 6 months of corrected age (i.e. 6 months from estimated date of delivery according to first‐trimester crown–rump length). Cardiovascular evaluation included a comprehensive echocardiographic assessment in both fetuses and infants and blood pressure and aortic intima–media thickness (aIMT) measurement in infants. Parameters were adjusted by linear regression analysis for gender, gestational age at delivery, pre‐eclampsia, prenatal glucocorticoid exposure, Cesarean delivery, admission to neonatal intensive care unit and body surface area. Results Both pre‐ and postnatally, when compared with controls, the SGA group showed a more globular cardiac shape (left sphericity index: controls 2.06 vs SGA 1.87 (P = 0.022) prenatally and 1.92 vs 1.67 (P = 0.007) postnatally), as well as signs of systolic longitudinal dysfunction (systolic annular peak velocity (S′): 7.2 vs 6.3 cm/s (P = 0.003) prenatally and 7.9 vs 6.4 cm/s (P < 0.001) postnatally; tricuspid annular plane systolic excursion: 7.2 vs 6.8 mm (P = 0.015) prenatally and 16.0 vs 14.2 mm (P < 0.001) postnatally) and diastolic dysfunction (left isovolumetric relaxation time: 46 vs 52 ms (P < 0.001) prenatally and 50 vs 57 ms (P = 0.034) postnatally). In addition, infants in the SGA group had increased mean blood pressure (mean: 61 vs 70 mmHg, P < 0.001) and maximum aIMT (0.57 vs 0.66 mm; P < 0.001). Conclusions Primary cardiovascular changes are already present in the SGA fetus and persist at 6 months of age. These data support prenatal cardiovascular remodeling as a mechanistic pathway of increased risk later in life in cases of SGA, regardless of Doppler abnormalities.application/pdfengThis is the pre-peer reviewed version of the following article: Cruz-Lemini M, Crispi F, Valenzuela-Alcaraz B, Figueras F, Sitges M, Bijnens B, Gratacós E. Fetal cardiovascular remodelling persists at 6 months of life in infants with intrauterine growth restriction. Ultrasound Obstet Gynecol. 2016; 48(3): 349-356, which has been published in final form at http://dx.doi.org/10.1002/uog.15767. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/uog.15767Cardiovascular remodelingCardiovascular riskFetal echocardiographyFetal programminginfo:eu-repo/semantics/openAccess