Otun, SarahEscrich Montañana, AinoaAchilonu, IkechukwuRauwane, MolemiLerma-Escalera, Jordy AlexisMorones-Ramírez, José RubénRios-Solis, Leonardo2023-09-132023-09-132023Otun S, Escrich A, Achilonu I, Rauwane M, Lerma-Escalera JA, Morones-Ramírez JR, Rios-Solis L. The future of cassava in the era of biotechnology in Southern Africa. Crit Rev Biotechnol. 2023;43(4):594-612. DOI: 10.1080/07388551.2022.20487910738-8551http://hdl.handle.net/10230/57854Cassava (Manihot esculenta) is a major staple food and the world's fourth source of calories. Biotechnological contributions to enhancing this crop, its advances, and present issues must be assessed regularly. Functional genomics, genomic-assisted breeding, molecular tools, and genome editing technologies, among other biotechnological approaches, have helped improve the potential of economically important crops like cassava by addressing some of its significant constraints, such as nutrient deficiency, toxicity, poor starch quality, disease susceptibility, low yield capacity, and postharvest deterioration. However, the development, improvement, and subsequent acceptance of the improved cultivars have been challenging and have required holistic approaches to solving them. This article provides an update of trends and gaps in cassava biotechnology, reviewing the relevant strategies used to improve cassava crops and highlighting the potential risk and acceptability of improved cultivars in Southern Africa.application/pdfeng© 2022 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/bync-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/07388551.2022.2048791BiofortificationCRISPR/Cas9Manihot esculentaBiosafetyBiotechnologyCassava mosaic diseaseCyanogen glycosideGenome editingPost-harvest deteriorationinfo:eu-repo/semantics/openAccess