Oliveira da Cruz, Jose F.Busquets Garcia, Arnau, 1985-Zhao, ZheVarilh, MarjorieLavanco, GianlucaRobin, LaurieCannich, AstridJulio-Kalajzić, FranciscaLesté-Lasserre, ThierryMaître, MarlèneDrago, FilippoMarsicano, GiovanniSoria-Gómez, Edgar2021-06-092021-06-092020Oliveira da Cruz JF, Busquets-Garcia A, Zhao Z, Varilh M, Lavanco G, Bellocchio L, et al. Specific hippocampal interneurons shape consolidation of recognition memory. Cell Rep. 2020 Aug 18; 32(7): 108046. DOI: 10.1016/j.celrep.2020.1080462211-1247http://hdl.handle.net/10230/47808A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB1Rs in D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D1-dependent manner. This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.application/pdfengCopyright © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.celrep.2020.108046CB(1) receptorD(1) receptorGABADopamineEndocannabinoid systemHippocampusInterneuronsLong-term potentiationNovel object recognition memoryinfo:eu-repo/semantics/openAccess