Sanchís, PilarPrieto, Rafael M.Konieczna, JadwigaGrases, FélixAbete, ItziarSalas Salvadó, JordiMartín, VicenteRuiz-Canela, MiguelBabio, NancyGarcía-Gavilán, Jesús FranciscoGoday Arno, AlbertoCosta-Bauza, AntoniaMartínez, José AlfredoRomaguera Bosch, Dora2024-04-092024-04-092023Sanchis P, Prieto RM, Konieczna J, Grases F, Abete I, Salas-Salvadó J, et al. Estimated phytate intake is associated with bone mineral density in mediterranean postmenopausal women. Nutrients. 2023 Apr 6;15(7):1791. DOI: 10.3390/nu150717912072-6643http://hdl.handle.net/10230/59691The main objective of this work was to explore the association of dietary phytate intake with bone mineral density (BMD) in a Mediterranean population of postmenopausal women. For this purpose, a cross-sectional analysis of 561 women aged 55-75 years with overweight/obesity and metabolic syndrome from a Mediterranean area and with data on dual-energy X-ray absorptiometry (DXA) scans in femur and lumbar spine was performed. Estimated phytate intake was calculated using a validated food frequency questionnaire. Our results indicated that phytate intake was associated with BMD [β(95%CI) per each 25 mg/100 kcal] in femoral neck [0.023(0.060-0.040) g/cm2], femoral Ward's triangle [0.033(0.013-0.054) g/cm2], total femur [0.018(0.001-0.035) g/cm2], and all the analyzed lumbar spine sites [L1-L4: 0.033(0.007-0.059) g/cm2] after adjusting for potential confounders. The sensitivity analysis showed that phytate intake was directly associated with lumbar spine BMD in women younger than 66 years, with a body mass index higher than 32.6 kg/cm2 and without type 2 diabetes (all p-for interactions < 0.05). The overall results indicated that phytate, a substance present in food as cereals, legumes and nuts, was positively associated with BMD in Mediterranean postmenopausal women. Phytate may have a protective effect on bone resorption by adsorbing on the surfaces of HAP. Nevertheless, large, long-term, and randomized prospective clinical studies must be performed to assess the possible benefits of phytate consumption on BMD in postmenopausal women.application/pdfeng© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/nu15071791DXABone mineral densityPhytatePostmenopausal womeninfo:eu-repo/semantics/openAccess