Brune-Ingebretsen, SynneHøgestøl, Einar A.de Rosbo, Nicole KerleroBerg-Hansen, PålBrunborg, CathrineBlennow, KajZetterberg, HenrikPaul, FriedemannUccelli, AntonioVilloslada, PabloHarbo, Hanne F.Berge, Tone2025-04-292025-04-292023Brune-Ingebretsen S, Høgestøl EA, de Rosbo NK, Berg-Hansen P, Brunborg C, Blennow K, et al. Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis. J Neuroimmunol. 2023 Sep;382:578175. DOI: 10.1016/j.jneuroim.2023.5781750165-5728http://hdl.handle.net/10230/70235Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.application/pdfeng© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jneuroim.2023.578175Multiple sclerosisSerum neurofilament light chainImmune cell subset frequenciesBiomarkersDisease worseninginfo:eu-repo/semantics/openAccess