Poliński, PatrykMiret-Cuesta, MartaIrimia Martínez, Manuel2025-07-232025-07-232025Poliński P, Cuesta MM, Irimia M. ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay. Cytoskeleton (Hoboken). 2025 Jun 9. DOI: 10.1002/cm.220511949-3584http://hdl.handle.net/10230/70977Data de publicació electrònica: 09-06-2025Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.application/pdfeng© 2025 The Author(s). Cytoskeleton published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/cm.22051ARCAlternative splicingForminSynapseinfo:eu-repo/semantics/openAccess